GHB (gamma hydroxybutyrate)

Since about 1990, GHB has been abused in the U.S. for euphoric, sedative, and anabolic (body building) effects. It is a central nervous system depressant that was widely available over-the-counter in health food stores during the 1980s and until 1992. It was purchased largely by body builders to aid fat reduction and muscle building. Street names include Liquid Ecstasy, Soap, Easy Lay, and Georgia Home Boy. Even though GHB may be difficult to distinguish from water, it has appeared in law enforcement indicators, including seizures of large amounts in Minneapolis/St. Paul and Phoenix.

Coma and seizures can occur following abuse of GHB and, when combined with methamphetamine, there appears to be an increased risk of seizure. Combining use with other drugs such as alcohol can result in nausea and difficulty breathing. GHB may also produce withdrawal effects, including insomnia, anxiety, tremors, and sweating.
GHB and two of its precursors, gamma butyrolactone (GBL) and 1,4 butanediol (BD) have been involved in poisonings, overdoses, date rapes, and deaths. These products, obtainable over the internet and sometimes still sold in health food stores, are also available at some gyms, raves, nightclubs, gay male parties, college campuses, and the street. They are commonly mixed with alcohol (which may cause unconsciousness), have a short duration of action, and are not easily detectable on routine hospital toxicology screens.

GHB emergency room mentions increased from 55 in 1994 to 2,973 in 1999.** In 1999, GHB accounted for 32 percent of illicit drug-related poison center calls in Boston. In Chicago and San Francisco, GHB use is reportedly low compared with MDMA, although GHB overdoses seem frequent compared with overdoses related to other club drugs.